Adsorption resin/polyethersulfone membrane used for plasma separation and middle molecular toxins adsorption

Abstract

Accumulation of endogenous and exogenous toxins in patients with chronic kidney disease increases the kidney burden. The newly developed plasma separation adsorption membranes provide a new model for the removal of middle molecular toxins. In this study, the adsorption resin LX-1000H is physically pulverized and blended into polyethersulfone matrixes to prepare adsorption resin/polyethersulfone (AR/PES) membranes by nonsolvent-induced phase separation for plasma separation and middle molecular toxins absorption. The results show that the static adsorption capacity of AR/PES membrane for lysozyme (a typical mimic of middle molecular toxins) is up to 108.90 mg/g, which is 4 times that of AR. The maximum dynamic adsorption capacity reaches 102.80 mg/g, which is 93.4% of static adsorption. The adsorption process is more consistent with the Langmuir model and the quasi-first-order kinetic model. The permeability of bovine serum albumin in simulated blood surpasses 90% and the cattle blood separated by AR/PES membrane is colorless and transparent. The AR/PES membrane surface presents electronegative at pH 7.4 and the water wettability is enhanced with the doping amount. No hemolysis and negligible leakage indicated favorable hemocompatibility. This paper is devoted to providing a strategy for plasma separation and adsorption membranes.