Abstract
Von Willebrand factor is adsorbed from plasma by fibrillar collagen in a manner which is dependent upon the time of incubation and collagen concentration. The adsorption does not require divalent cations and is temperature independent. As purified von Willebrand factor is also adsorbed by fibrillar collagen it is unlikely that the adsorption is mediated by other plasma proteins. Denatured collagen has no effect on von Willebrand factor activity and does not inhibit the adsorption of the factor by native fibrillar collagen. The adsorbed von Willebrand factor can be eluted from fibrillar collagen with 1M NaCl. The similarities between the adhesion of platelets to collagen and the adsorption of von Willebrand factor by collagen suggest that von Willebrand factor may have a role in collagen-platelet adhesion. The observed inhibition of platelet adhesion to collagen by antiserum to von Willebrand factor is consistent with this hypothesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
