Abstract
The adsorption of four cytotoxic drugs, vinblastine, vincristine, doxorubicin and mitozantrone, to in-line intravenous filters and giving lines has been investigated using the slow administration rates used in clinical practice. Adsorptive losses to polyethylene lines were negligible. The maximal loss to a Polyvinylchloride line was 9% for vincristine during the first hour of administration. Doxorubicin, vinblastine and vincristine were adsorbed to Pall ELD 96 h filters; up to 35% of the potency was lost during the initial hour of delivery. No adsorption could be detected for mitozantrone to the Pall ELD 96 h filter nor for all drugs to filters composed of polysulphone or cellulose acetate. The extent of adsorption for vinblastine, vincristine and doxorubicin to the Pall ELD 96 h filter increased as the pH of their solutions was increased from 4.5 to 7.8.
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