Abstract
Ultrathin gold nanofilms (≈ 50 nm) are suitable for detection of adsorbed molecules at solid- liquid interface of various sizes due to their surface plasmon resonance (SPR) properties. This SPR tech- nique makes it possible to study the surface adsorption in nanomol range amount on gold surfaces of a maximum of one mm 2 and to determine the adsorbed amount as a function of equilibrium concentration. Adsorption of L-cysteine, L-glutathione, ibuprofen and dopamine on the gold surface was examined. Moreover, the binding capability of ibuprofen and dopamine molecules on the gold surface functionalized by L-cysteine and L-glutathione was studied as well. Adsorption isotherms were recorded using the flow measuring technique, which allows determination of the amount of adsorbed material even in the nmol/cm 2 order of magnitude, the cross sectional areas of adsorbed molecules. The adsorption enthalpies (isosteric heat of adsorption) were determined from adsorption isotherms at different temperatures. The surface orientations of the studied molecules were analyzed by MarvinSketch program. (doi: 10.5562/cca2343)
Highlights
IntroductionSince the first report on the phenomenon of surface plasmon resonance (SPR) (studies on processes taking place on metal surfaces and the detection of gases), appliances have undergone an enormous development regarding both technique and applications
Since the first report on the phenomenon of surface plasmon resonance (SPR), appliances have undergone an enormous development regarding both technique and applications
SPR measurements were carried out in order to determine the adsorbed amounts and the monomolecular coverage of L-cysteine (L-Cys), L-glutathione (L-GSH), ibuprofen and dopamine on the gold surface, as well as adsorption of ibuprofen and dopamine on the gold surface functionalized with L-cysteine and Lglutathione
Summary
Since the first report on the phenomenon of surface plasmon resonance (SPR) (studies on processes taking place on metal surfaces and the detection of gases), appliances have undergone an enormous development regarding both technique and applications. Since the first presentation of a surface plasmon resonance (SPR) gas sensor[1,2] the scientific attention focusing on these instruments has been undiminished. Development of SPR devices serving for studies on chemical and biological analytes is pursued intensively, so that number of publications reporting studies on interactions of importance for medical diagnostics, environmental protection, bacteriology and food quality increases rapidly. The most popular configuration is the socalled Kretschmann-configuration (Figure 1), in which the momentum of incident light is coupled to the free oscillations of the conduction electrons at a metal surface through a prism in order to increase the wavenumber of light, generating the conditions of surface plasmon resonance
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