Abstract
ABSTRACTThe complexation behaviour of linear DNA (negatively charged) with surface functionalised sub-micron latex spheres is studied by dynamic light scattering (DLS), small-angle neutron scattering (SANS), small-angle x-ray scattering (SAXS), and micro rheology. The complexes are measured in solution as a function of component concentration (CDNA, CSPH) and added salt concentration (Cs). In the absence of salt, measured radius increases with CDNA (CSPH held constant) up to a plateau value. The presence of salt causes a decrease in the measured complex radius, which may be due either to increased flexibility of the chains allowing them to form a more compact layer on the sphere surface, or dissociation of the two components due to screened electrostatics. More detailed experiments to determine this are underway.
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