Abstract
The adsorption behavior of chlorhexidine gluconate (CHG) to absorbent cotton and gauze was investigated in order to elucidate the lowering of CHG concentration in aqueous solution immersed surgical cotton. CHG was scarcely adsorbed to plastic containers. The residual percentage of CHG in 0.02 and 0.05% CHG solutions containing 3% absorbent cotton fell in 2 days to 14 and 54%, respectively. In the case of 8% cotton, the residual percentage in the same solutions fell to 14 and 39%. Although the residual percentage differed with CHG concentration or quantities of cotton, the adsorption isotherms uniformly showed Langmuir type, and the amount adsorbed was about 9 mg/ g of absorbent cotton at the equilibrium concentration of more than 0.05%, as compared with 3 mg/ g in the case of gauze. Though the amount adsorbed was small, as indicated above, the effect of adsorption on bactericidal activity is not neigligible in view of the low CHG concentration used in hospitals. It is, therefore, desired that the amount of adsorption is taken into consideration when the CHG solutions are prepared.
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