Abstract
Poly(vinyl acetate) (PVAc) particles find many uses in the biomedical field, including the use as particle embolizers. Particularly, embolizing particles can combine physical and chemical effects when they are doped with pharmaceuticals. For this reason, the adsorption of bovine serum albuminum (BSA) and lysozyme (used as model biomolecules) on PVAc particles produced through suspension polymerization is studied in the present manuscript in a broad range of pH values. It is shown that significant amounts of BSA and lysozyme can be adsorbed onto PVAc particles in the vicinities of the isoelectric point of the biomolecules (0.65mg of BSA and 1.0mg of lysozyme per g of PVAc), allowing for production of chemoembolizers through adsorption. Particularly, it is shown that lysozyme still presents residual activity after the adsorption process, which can constitute very important characteristic for real biomedical applications.
Highlights
Different methods have been used to load drugs spherical Poly(vinyl acetate) (PVAc)/poly(vinyl alcohol) (PVA) particles with core-shell morphology into polymer matrices, to be used as embolizers
Based on the results presented in the previous paragraphs for the model biomolecules bovine serum albuminum (BSA) and lisozyme, the adsorption of proteins onto PVAc microparticles seems to be controlled by hydrophobic interactions, depending on the availability of interfacial surface, and depending significantly on the mobility of the polymer chains
It can be conjectured that as much as 1mg of protein can be loaded into 1g of PVAc-based embolic agents through adsorption, if the adsorption process is performed in the vicinities of the isoelectric point of the protein of interest, which is comparable to the amounts required for some of the standard chemoterapic procedures
Summary
Different methods have been used to load drugs spherical PVAc/PVA particles with core-shell morphology (or biological active substances) into polymer matrices, to be used as embolizers. Based on this process, additional including co-precipitation, in-situ incorporation and studies were carried out to modify the final properties of adsorption[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Embolization techniques have been used to treat radius of 3.48nm[38,39,40]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
