Abstract

Adsorptions of ΦCOOH, ΦSO 2NHΦ and ΦSO 2NH pyrimidine were studied by a differential capacitance method at pH=12 at the dropping mercury electrode. The interfacial behaviour of each compound was compared with that of the corresponding p-amino derivative: The experimental γ max values are approximately the same, while the experimental −Δ G ads o, at constant potential, are lower by a constant contribution. Moreover, the two oxygen atoms still seem to be directly involved in the adsorption process. Finally, the relevance of the p-NH 2 substitution on the pharmacological properties of these compounds is discussed.

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