Abstract
Activity, uptake and disposition of two related bisbiguanide antiseptics alexidine and chlorhexidine, were investigated. Rates of onset of membrane damage were faster following alexidine than chlorhexidine treatment. Deep-rough strains of E. coli were less sensitive than their smooth counterparts. Whilst the uptake of both agents to whole cells corresponded to ‘C-type’, alexidine demonstrated additional high affinity uptake (‘H-type’) at low applied drug concentrations. Distribution studies for the absorbed biocide indicated that the agents must saturate a number of envelope targets before penetration to the cytosol is possible. Alexidine possessed a higher affinity towards these sites than chlorhexidine.
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