Abstract
Phenylboronic acid-bearing polyamidoamine dendrimer (PBA-PAMAM)/poly(vinyl alcohol) (PVA) multilayer films were prepared through the layer-by-layer (LbL) deposition of PBA-PAMAM solution and PVA solution. PBA-PAMAM/PVA films were constructed successfully through the formation of boronate ester bonds between the boronic acid moiety in PBA and 1,3-diol units in PVA. When the (PBA-PAMAM/PVA)5 films were immersed in rose bengal (RB) solution, RB was adsorbed onto the LbL films. The amount of RB adsorbed was higher in the LbL films immersed in acidic solution than in basic solution. The release of RB from the LbL films was also promoted in the basic solution, while it was suppressed in the acidic solution. The boronic acid ester is oxidized to phenol by hydrogen peroxide (H2O2) and the carbon-boron bond is cleaved, so that the (PBA-PAMAM/PVA)5 films can be decomposed by immersion in H2O2 solution. Therefore, when RB-adsorbed (PBA-PAMAM/PVA)5 films were immersed in H2O2 solution, the release of RB was moderately promoted when the solution was weakly acidic.
Highlights
Layer-by-layer (LbL) films have been developed for separation membranes [1,2], sensors [3,4,5], and capsules as controlled release systems [6,7,8,9]
A quartz slide was alternately immersed in the phenylboronic acid (PBA)-PAMAM and the poly(vinyl alcohol) (PVA) solutions, and the absorbance of the quartz slide was measured each time (Figure 5)
When the quartz plate was in the PBA-PAMAM solution, absorption was observed at 250 nm
Summary
Layer-by-layer (LbL) films have been developed for separation membranes [1,2], sensors [3,4,5], and capsules as controlled release systems [6,7,8,9]. Thin films with various functions can be developed using polymers that are suitable for the intended application In this context, we have focused on the preparation of thin films using dendrimers. Many LbL films prepared using electrostatic interaction as as aa force have been reported. Suwa et al recently reported that LbL films were prepared by combining PBA-bearing(PBA-PAMAM). If the LbL films using PBA-PAMAM can be be to stimuli, they be applied as athey drugcould reservoir for controlled drug releasefor systems.
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