Abstract
Total intracellular and DNA-associated uptake of Adriamycin (ADR) was studied in V79 Chinese hamster cells and in a derived subline which is resistant to ADR killing. For both sublines, uptake of ADR was dependent on cell density with greater uptake seen with less dense cultures. Drug uptake was markedly less in the ADR-resistant cells compared to parent V79 cells. These results suggest that the resistance observed is in large part due to membrane changes that result in decreased drug uptake.
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