Abstract
Bronchopulmonary dysplasia(BPD)is a common respiratory disease in premature infants characterized by alveolar and pulmonary vascular dysplasia.There are currently no effective preventive and therapeutic measures.Adrenomedullin(ADM)is a vasodilator peptide produced by endothelial and smooth muscle cells of the systemic and pulmonary circulation, which promotes alveolar growth and pulmonary angiogenesis.ADM protects the respiratory system through three signaling pathways: (1)it promotes pulmonary vascular endothelial cell proliferation through extracellular regulated protein kinases(ERK); (2)attenuates lung cell apoptosis and improves cell proliferation through protein kinase B(PKB)pathway; (3)it down-regulates NADPH oxidase 4(NOX4)expression in lung tissue to inhibit oxidative stress and improves BPD.So ADM signaling axis may be a potential therapeutic target for human infants with BPD.It provides theoretical basis for clinical prevention and treatment of BPD in premature infants. Key words: Bronchopulmonary dysplasia; Adrenomedullin; Extracellular regulated protein kinases; Protein kinase B; Nicotinamide adenine dinucleotide phosphate oxidase 4
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