Abstract
1. 1. Grouper ( Epinephelus akaara) brains were heated and then extracted with a mixture of water, hydrochloric acid and acetone. An acid acetone powder was formed by adding the brain extract into a large volume of chilled acetone and subsequently recovering the precipitate. 2. 2. The precipitate was dissolved and subjected to salt fractionation and gel nitration on Sephadex G-10. 3. 3. The resultant unretarded fraction stimulated corticosterone production in isolated rat adrenal cells and exhibited opiate receptor binding activity. 4. 4. A fraction retarded on Sephadex G-10 possessed opiate receptor binding but not corticosteroidogenic activity. 5. 5. The data suggest the elaboration of ACTH-like and opiate-like materials by the grouper brain.
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