Abstract
IN A PREVIOUS paper it was stated that the ground squirrel survives adrenalectomy if the food intake is maintained, which occurs if the animal is allowed to drink i per cent sodium chloride solution (Groat, 1941). A lessened food intake and the inability to survive a fast are good criteria of two different levels of adrenal insufficiency in this animal. At a variable time after adrenalectomy (minimum, 15 days for females), I per cent sodium chloride solution may be replaced by water and the animal will continue to eat; but it will not be able to survive-a fast until some 3 or 4 months after operation. The nature of this gradual physiologic adjustment has proved to be the appearance and growth of adrenocortical-like tissue in the animal. The ovary is an invariable site for the manifestation of this phenomenon. The material for this report consists of serial sections of the ovaries of 46 ground squirrels.
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