Abstract
Summary Surgical damage to the adrenal gland caused by major gastric surgery has been reported in the literature; however, the influence on adrenocortical function has not been investigated and the frequency of its occurrence is uncertain. In ten patients with carcinoma of the stomach the functional adrenocortical reserve was determined before and after major gastric surgery. A Synacthen stimulation test was performed. Significant differences between the pre- and postoperative maximal increments in the plasma 11-OHCS level could not be demonstrated. The clinical course of the patients was uneventful. We have concluded that surgical damage to the adrenal gland of functional significance could not be demonstrated. That significant functional damage may occur has not been excluded, but its frequency must obviously be minimal.
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