Abstract
Abstract Shuttlebox avoidance learning in rats is a U-shaped function of time after original avoidance training. The descending limb of the function is correlated with a decrease in plasma concentration of corticosterone. When high corticosteroid levels are maintained, either by exogenous ACTH administration or by hydrocortisone replacement, then high levels of performance are maintained. These findings support the hypothesis that avoidance learning decrements at intermediate intersession intervals are directly related to the functioning of the neuroendocrine system.
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