Abstract
The adrenoceptors and cholinoceptors in the isolated rabbit iris dilator and sphincter muscles were studied. It was concluded that the dilator, as well as the sphincter, contains α- and β-adrenoceptors according to Ahlquist's classification. In the dilator, the α-receptor was the dominant receptor, and stimulation of these receptors caused a contraction. There were few β-receptors in this muscle and they were inhibitory in function. The sphincter contained both kinds of adrenoceptors and stimulation caused relaxation. Cholinoceptors of the atropine sensitive type, were numerous in the constrictor. In the isolated dilator preparation, acetylcholine produced a weak contraction that was reversed by atropine into a weak relaxation. Atropine itself produced a weak contraction of the muscle.
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