Abstract
The stimulation of adrenoreceptors by epinephrine leads to an alteration in the Ca 2+ homeostasis of rat submandibular cells. The relative contributions of α- and β-adrenoreceptors were assessed with specific adrenergic agents. Stimulation of α 1-adrenoreceptors resulted in enhanced unidirectional 45Ca 2+ fluxes, while such effects following β-adrenoreceptor stimulation, though suggestive, were equivocal. When the cytosolic Ca 2+ level was followed in cells pre-loaded with the Ca 2+-sensitive fluorescent indicator Quin 2, clear results were observed. Both α 1- and β-adrenoreceptor stimulation were capable of mobilizing intracellular and extracellular Ca 2+ pools, as assessed by differential responses of cells incubated in media (±)-ethylene-glycol-bis-( β-aminoethyl ether)-N,N′-tetraacetic acid. However, Ca 2+ mobilization following α 1-adrenoreceptor stimulation was more rapid (initial rate ∼ 4–5 ×) and to a greater extent (∼ 2 ×) than seen with β-adrenoreceptor stimulatio.
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