Abstract
The effect of adrenergic influences on Met-enkephalin concentrations in median eminence, neurointermediate pituitary and hypothalamus outside median eminence were examined. Met-enkephalin levels in median eminence were augmented by administration of the alpha 1-adrenergic agonist methoxamine acutely or chronically and decreased by the selective depletion of adrenergic transmitters by 6-hydroxydopamine. Met-enkephalin levels in neurointermediate lobe were decreased by methoxamine but unaffected by depletion of noradrenaline/adrenaline. These results indicate that adrenergic mechanisms maintain Met-enkephalin concentrations tonically in median eminence and deplete Met-enkephalin concentrations in neurointermediate lobe. These results suggest differential adrenergic regulation of hypothalamic proenkephalin neurons terminating in median eminence and neural lobe of pituitary.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.