Abstract
Endothelin was tested for possible interactions with the noradrenergic neuroeffector transmission in guinea pig pulmonary artery. Endothelin concentration-dependently enhanced nerve-induced contractile responses and concomitantly increased basal tone. Furthermore, endothelin inhibited the stimulation-evoked release of [ 3H]noradrenaline and enhanced the contractile response to exogenously applied noradrenaline. These results suggest that endothelin, in addition to its direct contractile effect, may function as a modulator of adrenergic neuroeffector transmission in the guinea pig pulmonary artery via both stimulatory post- and inhibitory prejunctional mechanisms.
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