Abstract
Intravenous infusion of epinephrine (Adrenaline) or of isoprenaline stimulates the heart and causes tachycardia. These amines, according to Ginsburg and Cobbold,<sup>1</sup>stimulate respiration, increasing the depth of breathing rather than the rate. The stimulation of respiration by isoprenaline is more powerful, and unlike that caused by epinephrine, is sustained during an intravenous infusion. Oxygen consumption increases together with the increase in respiration, the rise being greatest with isoprenaline and least with noradrenaline. The relative order of potency of the 3 amines with respect to vascular and respiratory effects is isoprenaline, epinephrine, and noradrenaline. Noradrenaline exerts a direct constrictor action on the blood vessels of skeletal muscle. With intravenous infusions there is generally a similar degree of constriction, although in some subjects an initial transient increase in forearm flow has been recorded. This dilatation is apparently an indirect effect of noradrenaline, dependent on sympathetic activity. By
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