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Abstract
Abstract: The influence of adrenergic and serotoninergic mechanisms on gastric secretion was investigated using fistula‐ and pylorus‐ligated rats. Secretion was increased by the tyrosine hydroxylase inhibitor α‐methyltyrosine. This effect could be reversed by L‐DOPA. 6‐hydroxydopamine also increased gastric output. The tryptophane hydroxylase inhibitor p‐chlorophenylalanine reduced gastric output and abolished the increase in gastric secretion induced by α‐methyltyrosine.The antisecretory effect of serotonin was found to be antagonized by α‐methyltyrosine. Pre‐treatment with 6‐hydroxydopamine also diminished the anti‐secretory effect of serotonin.The results indicate the possibility of the existence of an inhibiting peripheral adrenergic tonus in the regulation of gastric secretion in rats. Furthermore it is suggested, that the anti‐secretory effect of large doses of serotonin may be due to displacement of noradrenaline in catecholamine neurones. Finally the question is raised whether a balance between serotoninergic and adrenergic mechanisms in the regulation of gastric secretion may exist in rats.
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