Abstract
The influence of drugs which modify brain amine concentration was studied on morphine-induced respiratory depression in decerebrate cats. Resting and CO2-stimulated respiration were evaluated. The respiratory depression was partially antagonized by pretreatment with reserpine and p-chlorophenylalanine; enhanced by two monoamine oxidase inhibitors, pargyline and tranylcypromine, and, to some extent, by α-methyl-tyrosine. It was not changed by intracerebral 6-hydroxydopamine. The results show that, as with the other central actions of morphine, the presence of 5-HT is necessary for morphine activity to be complete. The change in the level of brain amines also modified the respiratory activity in a way that suggests that the respiratory center is stimulated by adrenergic and damped by serotonergic tone.
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