Abstract
Adrenergic drugs from several chemical classes were compared with clonidine as protectants against soman toxicity. All agents tested produced some degree of protection. Alpha-adrenergic agonists such as methyldopa, xylazine and clonidine were among the most effective drugs, while a dopaminergic agonist (bromocriptine) and β-receptor antagonist (pindolol) were the least effective. Potency for protection was related to affinity for α-adrenergic binding sites labelled with [ 3H]clonidine. Atropine acted synergistically with adrenergic agonists to potentiate protection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
