Abstract
In this study, the effect of dopamine as agonist dopaminergic receptor and alpha and beta adrenergic receptor was studied both in vivo. The effect of tolazoline as an antagonist of alpha-2 adrenergic receptor was also studied in patients with bronchial asthma and persons with increased bronchial reactibility. Parameters of the lung function are determined by body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines – Asema. Results gained in vivo shows that stimulation of alpha adrenergic receptor with dopamine (4 μg and 300 μg) causes significant contraction (p > 0.1) of the smooth bronchial musculature. Whereas, blockage of alpha-2 adrenergic receptor with tolazoline (20 mg by inhalator ways) does not change the bronchimotor tonus significantly (p>0.1) when compared to the stimulation of beta-2 adrenergic receptor with hexoprenaline (2 inh. x 0.2 mg) and blocker of cholinergic receptor - ipratropium (2 inh. x 1 mg). Reaction of the smooth musculature to dopamine suggests that this substance may cause constriction through alpha adrenergic receptors. Reaction may also be intermediated in indirect ways through dopaminergic receptor of the cholinergic transmission, with intracellular inhibition of the creation of cAMP.
Highlights
Dopamine has many functions which, as of yet, are not fully clarified
D2 dopaminergic receptor are mainly placed in presynaptic nerve endings and their stimulation does not cause the activation of adenylate cyclase, but it leads towards its inhibition which is manifested by the reduction of cAMP production [5]
We have undergone this study in order to evaluate the effect the stimulation and the blockage of alpha adrenergic receptor with dopamine and tolazoline has on the response of the airways smooth musculature in persons with bronchial asthma
Summary
Dopamine has many functions which, as of yet, are not fully clarified. dopamine in high doses stimulates alpha and beta adrenergic receptor, physiologic endogen actions of dopamine are intermediated primarily by dopaminergic receptors. Experiments conducted in vivo prove that clonidine intermediates an inhibitor control of the existing vagal activity These results are not verified by other researchers [12]. Alphaadrenergic antagonists (e.g. indoramin) cause the bronchodialation due to the blocking of alpha-adrenergic receptors and can be useful therapeutics for certain asthmatic populations [16] It remains unclear whether these results are caused by the blockage of stimulation of the mastocyte’s alpha-adrenergic receptor, or the airways smooth muscles [17]. We have undergone this study in order to evaluate the effect the stimulation and the blockage of alpha adrenergic receptor with dopamine and tolazoline has on the response of the airways smooth musculature in persons with bronchial asthma
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