Abstract
Aims: This study was conducted to find the effect of adrenaline and nor adrenaline containing local anesthesia on the blood glucose level on non insulin dependent diabetic patients. Materials and Methods: Thirty patients were given 1.8ml of 2% lignocaine containing 1:100000 adrenaline as infiltration local anesthesia intraorally, and other thirty patients received 1.8ml of 2%lignocaine containing 0.072mg of nor–adrenaline in the same manner. Fasting blood sugar was measured before the administration of local anesthesia and 30 minutes after the administration of local anesthesia. Results: There were no significant differences in blood glucose level measured before and after the injection of adrenaline containing local anesthesia. However, there were significant differences between the results obtained with nor–adrenaline containing local anesthesia, where there is a significant increase in blood glucose level 30 minutes after the injection of local anesthesia. Conclusions: The administration of anesthesia containing adrenaline has no effect on blood glucose level of diabetic patients. While administration of anesthesia containing nor adrenaline cause a significant effect (hyperglycemic effect) in those patients.
Highlights
The administration of local anesthesia during dental treatment such as simple tooth extraction to help in pain controlling during dental operation and to control postoperative pain, and the use of vasoconstrictor containing solution aids heamostaises [1,2].The systemic effect attributed to the injection of local anesthesia solutions have been the subject of discussion for many years[3,4,5,6]
The study sample consisted of 60 volunteers of non insulin dependence diabetes mellitus patients (NIDDM)
Determination of blood glucose level was achieved by digital computerized device, drop of blood sample was obtained from the ventral surface of thumb
Summary
The systemic effect attributed to the injection of local anesthesia solutions have been the subject of discussion for many years[3,4,5,6]. Most of the debate, have been concerned with the hemodynamic effect of vasoconstrictor component in both healthy and medically compromised patients, evidence suggest that a quantities of adrenaline injected routinely during oral surgery procedure can produce biochemical changes in healthy volunteers [7, 8] and in patients having third molar surgery under local aneasthesia[9] It was a purpose of the present study to investigate biochemical effect of adrenaline and nor–adrenaline containing lignocain local anesthesia solution when used in clinical doses on fasting blood glucose level in non insulin dependence diabetes mellitus patients
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