Abstract
Ovariectomized mares (n = 6) were treated with intravenous saline or 67 or 667 μg of a synthetic ACTH fragment, (1–24)-OH, in a 2 × 3 crossover study. In mares receiving (1–24)-OH, plasma concentrations of cortisol were significantly (P < 0.01) elevated above those of control mares. Mares which received 667 μg (1–24)-OH had significantly (P < 0.01) elevated plasma concentrations of testosterone compared with mares which received the low dose of (1–24)-OH and with control mares. Plasma concentrations of estradiol and progesterone were not increased by administration of (1–24)-OH.
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