Abstract
The clinical manifestations of Neuroblastoma are very variable. They depend on the site of the primary tumor, most often in the abdomen, along the spine or in the adrenal gland. Very often, it is the existence of metastases which reveals the disease, with bone pain, and / or difficulty in walking or urinary problems. Management must be carried out in a specialized multidisciplinary team. This will confirm, by imaging, the existence of a neuroblastoma, perform a biological assessment, search for metastases from a distance, and define prognostic factors and the appropriate therapeutic strategy.
Highlights
Neuroblastoma is the most common extra-cranial solid malignant tumor in young children. It is a malignant tumor derived from cells originating in the tissues that give rise to the sympathetic nervous system
The tumor biopsy is used to look for abnormalities in the tumor chromosomes, which are used to classify the level of aggressiveness of the tumor: abnormalities in number of best prognosis
The therapeutic strategy is built taking into account these three factors: for tumors that can be immediately treated, surgery alone will most often be sufficient; for tumors that are not immediately operable, pre-surgical chemotherapy is necessary before surgery
Summary
Abstract the clinical manifestations of Neuroblastoma are very variable. They depend on the site of the primary tumor, most often in the abdomen, along the spine or in the adrenal gland Very often, it is the existence of metastases which reveals the disease, with bone pain, and / or difficulty in walking or urinary problems. Management must be carried out in a specialized multidisciplinary team. This will confirm, by imaging, the existence of a neuroblastoma, perform a biological assessment, search for metastases from a distance, and define prognostic factors and the appropriate therapeutic strategy
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