Abstract
The results of this study show that grafts of adrenal medulla into the rat brain parenchyma or ventricle produced significant blood-brain barrier dysfunction. Systematically administered protein rapidly entered either the grafts, the surrounding brain tissue or the cerebrospinal fluid. The grafted chromaffin cells avidly took up blood-borne radiolabelled amine. Thus, autonomic tissue transplants prevented normal reconstitution of the blood-brain barrier after surgery and indefinitely exposed host brain tissue to blood-borne compounds.
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