Abstract
Histoplasmosis is a fungal infection caused by a dimorphic, saprophytic fungus Histoplasma capsulatum with primary predilection for the lungs and disseminated infections occurring rarely. Our case illustrates the case of disseminated adrenal histoplasmosis in an immunocompromised 42-year-old diabetic man. Radiological diagnosis suggested bilateral malignant adrenal mass, most likely metastasis. FNAC yielded blood only. Excisional biopsy from left adrenal gland, Hematoxylin & Eosin staining along with special stains as Periodic Acid Schiff and Grocott’s Methenamine Silver were performed to yield the concluding diagnosis of histoplasmosis.
Highlights
Histoplasmosis is a fatal infectious granulomatous disease affecting people worldwide caused by a dimorphic saprophytic fungus Histoplasma capsulatum.[1]
Disseminated histoplasmosis occurs largely in immunocompromised patients but there have been cases reported in the literature in immunocompetent
The patient was convincingly diagnosed as adrenal histoplasmosis and started on Itraconazole with dramatic clinical improvement
Summary
Histoplasmosis is a fungal infection caused by a dimorphic, saprophytic fungus Histoplasma capsulatum with primary predilection for the lungs and disseminated infections occurring rarely. Our case illustrates the case of disseminated adrenal histoplasmosis in an immunocompromised 42-year-old diabetic man. Radiological diagnosis suggested bilateral malignant adrenal mass, most likely metastasis. Excisional biopsy from left adrenal gland, Hematoxylin & Eosin staining along with special stains as Periodic Acid Schiff and Grocott’s Methenamine Silver were performed to yield the concluding diagnosis of histoplasmosis. Reveived : January 19th 2019; Accepted : March14th 2019; Published : March 29th 2019.
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