Adrenal insufficiency in patients with acquired immunodeficiency syndrome-an underestimated problem

Deepak R Madi,Sathish Rao,Shashidhar Khanapure,Basavaprabhu Achappa,John Ramapuram

doi:10.1186/1742-4690-9-s1-p143

Deepak R Madi, Sathish Rao + Show 3 more

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https://doi.org/10.1186/1742-4690-9-s1-p143

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Journal: Retrovirology	Publication Date: May 25, 2012
Citations: 1	License type: CC BY 2.0

Affiliation: Manipal Academy of Higher Education

Abstract

Adrenal insufficiency is a serious complication of AIDS. Usually the integrity of HPA (Hypothalamo pituitary) axis is assessed by measuring cortisol response to 250µg of ACTH. Recent studies have shown that lower ACTH dose increases the sensitivity of the procedure. In the present study we have tried to estimate prevelance of adrenal insufficiency using low dose ACTH test (1µg).

Highlights

Adrenal insufficiency is a serious complication of AIDS
The integrity of HPA (Hypothalamo pituitary) axis is assessed by measuring cortisol response to 250μg of ACTH
Recent studies have shown that lower ACTH dose increases the sensitivity of the procedure

Summary

Introduction

Adrenal insufficiency is a serious complication of AIDS. The integrity of HPA (Hypothalamo pituitary) axis is assessed by measuring cortisol response to 250μg of ACTH. Recent studies have shown that lower ACTH dose increases the sensitivity of the procedure. In the present study we have tried to estimate prevelance of adrenal insufficiency using low dose ACTH test (1μg). Primary objective To estimate the prevelance of adrenal insufficiency in AIDS patients using low dose ACTH test. Research design and methods 50 patients with confirmed diagnosis of HIV were included in the study. Lab investigations included Cd4 count, serum cortisol and low dose acth stimulation test. Data of patients with adrenal insufficiency (GROUP 1) was compared with those without adrenal dysfunction (GROUP 2). Counts were high in (GROUP 1) when compared to (GROUP2)

Conclusion

Results