Adrenal insidentalomalı hastalarda metabolik parametreler

Abstract

Aim:Our aim is to determine the metabolic state in patients with incidental adrenal mass.Material and Methods: 67 patients in whom functional tests about adrenal incidental mass were assessed in University of Necmettin Erbakan, Faculty of Medicine, Department of Endocrinology and Metabolism, were admitted to the study. Results:Of these 67 patients, 34 were male and 33 were female. Mean age was 57.1±12, mean body mass index was 29.1±6 kg/m². In patients enrolled to the study; cushing’s syndrome, pheochromocytoma, primary hyperaldosteronism tests were performed. Functional adrenal mass was detected in 8 patients (6 pheochromocytoma, 1 cushing’s syndrome, 1 primary hyperaldosteronism). Impaired fasting glucose or type 2 diabetes were identified in 38 patients. Mean glucose was 127.6±18 mg/dL in all patients. Mean glucose in patients with functional and non-functional mass were 117.2±32 mg/dL and 129±62 mg/dL respectively. Mean systolic blood pressure was 125±18 mmHg, and diastolic blood pressure was 77±10.9 mmHg in all patients. Mean systolic pressure was 135±10.4 mmHg in patients with functional mass and 124±19 mmHg in patients with non-functional mass. Mean triglyceride was 157.5 ± 83 mg/dL (normal <150), HDL was 39.3 ± 9.5 mg/dL (normal <40) and LDL was 120.1 ± 37 mg/dL (normal <100) in all patients.Conclusion:In our study, impaired fasting glucose, indicating insulin resistance and Type 2 DM were detected in 56% of patients with adrenal incidentaloma. Although the mild cortisol excess by non-functional adrenal adenomas is not sufficient for the development of cushingoid appearance, it can lead to insulin resistance and its clinical consequences. Increased body mass index may be associated with subclinical Cushing’s syndrome in patients with incidentaloma