Abstract
RELATIVELY little is known regarding the role of the adrenal cortex in human pregnancy. Conflicting reports appear in the literature on steroid excretion-rates in women during normal pregnancy. Some workers1 have found no change in 17-ketogenic steroid excretion in the last trimester of pregnancy, while others2, using the same chemical method for their estimation, report a slight increase in levels. In contrast, Venning 3, employing a bioassay technique as a measure of adrenal activity, found an initial rise in excretion of glycogenic corticoids in the first trimester of human pregnancy. This later returned to normal values with a falling-off in excretion-rate usually occurring in the last month. Shortly after parturition the values were back to normal levels again.
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