Abstract
Adrenal levels of adrenaline and noradrenaline were determined in rats subjected to a 96 hour ethanol intoxication and in animals experiencing moderate to severe withdrawal behaviour. Adrenaline content of adrenal glands of animals sacrificed during intoxication and during withdrawal was less than 30% of treatment controls. The concentration of noradrenaline in withdrawing animals was 52% of control. Compensated adrenal weights of intoxicated animals were 80% larger than control values. These findings suggest that “binge-type” ethanol administration has profound effects on adrenal catecholamine levels and on adrenal gland weight.
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