Abstract

It has been known for many years that the liver can inactivate etitrogenic hormone or impair the function of ovarian tissue. It has, likewise, been found that epinephrine is destroyed in the liver since injections of it into the splenic vein produce about a fourth the rise in blood pressure that can normally be expected (Philpot and Cantoni, 1941). Progesterone, on the other hand, is not inactivated by liver pulp “in vitro” (Engel, 1944). There are also indications that the function of cortical tissue of the adrenal is not impaired by the liver since Eversole, Edelmann and Gaunt (1940) succeeded in maintaining the lives of two of ten rats with adrenal autografts in the liver. Failure in eight of their experiments may have been a matter of technique or the liver may have been antagonistic toward hypertrophy of the tissue of the adrenal.

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