Abstract
Cisplatin is a most valuable broad spectrum antineoplastic drug available for the treatment of testicular and ovarian cancers. It has several severe toxic side effects of which gastrointestinal and nephrotoxicity are the major dose limiting. It also induces hypocalcemia and Hypomagnesemia that have been demonstrated to effect the secretory activity of the neurohypophysis and the parathyroid glands. In rats cisplatin treatment causes stomach bloating and ulceration that can be ablated by daily injections of calcium just before the treatment and during the treatment or using vagotomy. Adrenalectomy has also been shown to prevent ulceration. Present study is an effort to determine the effect of cisplatin on morphological and cytochemical changes in the neuromuscular interactions of the stomach smooth muscle and the adrenal glands before and after vagotomy.Male Wistar rats [Crl:(WI)BR] weighing 200-300 g were given intraperitoneal injection of 9 mg/kg in 0.85% saline. Alternate group of animals received in addition daily injections of calcium (1 ml of 1.3% calcium chloride).
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