ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease.

Dong-Wei Wang,Min Liu,Xiang Zhan,Ping Wang,Luo-Sha Zhao,Yu-Qing Liu

doi:10.1590/s1415-475738420140234

Abstract

Recently, the rs1042713 G > A and rs1042714 C > G polymorphisms in the beta-2 adrenergic receptor (ADRB2) gene were shown to be related to atherosclerosis diseases. Therefore, we performed a systemic meta-analysis to determine whether the two functional polymorphisms are related to the risk of myocardial infarction (MI) and coronary artery disease (CAD). We identified published studies that are relevant to our topic of interest. Seven case-control studies, with a total of 6,843 subjects, were incorporated into the current meta-analysis. Our analysis showed a higher frequency of rs1042713 G > A variant in patients with MI or CAD compared to healthy controls. A similar result was also obtained with the rs1042714 C > G variant under both the allele and dominant models. Ethnicity-stratified subgroup analysis suggested that the rs1042714 C > G variant correlated with an increased risk of the two diseases in both Asians and Caucasians, while rs1042713 G > A only contributes to the risk of two diseases in Asians. In the disease type-stratified subgroups, the frequencies of both the rs1042713 G > A and rs1042714 C > G variants were higher in the cases than in the controls in both the MI and CAD subgroups. Collectively, our data contribute towards understanding the correlation between the rs1042713 G > A and rs1042714 C > G polymorphisms in ADRB2 and the susceptibility to MI and CAD.

Highlights

Coronary artery disease (CAD), the most common category of heart disease, is the leading cause of the hospital admissions, resulting in a high mortality in 2012 (Finegold et al, 2013)
We observed differences in the association of rs1042713 G > A and rs1042714 C > G polymorphisms with Myocardial infarction (MI) or CAD among different ethnicities, disease types and genotyping methods, and further Q-test analysis revealed the presence of heterogeneity (I2 > 90.5%, p < 0.05)
The subgroup analysis based on ethnicity showed that the rs1042714 C > G polymorphism in the ADRB2 was positively correlated to the risk of MI and CAD in both Asians and Caucasians (Figure 2)

Summary

Introduction

Coronary artery disease (CAD), the most common category of heart disease, is the leading cause of the hospital admissions, resulting in a high mortality in 2012 (Finegold et al, 2013). CAD is induced by a plaque of fat, cholesterol and white blood cells that accumulate along the inner walls arteries of the heart, which narrows the arteries and reduces the rate and mass of blood flow to the heart (Korosoglou et al, 2011). Myocardial infarction (MI), referred to as acute myocardial infarction (AMI), accounts for the majority of the overall mortality in CAD (Korosoglou et al, 2011). In 2010, over one million people in America experienced either their first or recurrent MI, and more than half of them died from it (Dupre et al, 2012). Additional symptoms include abnormal heartbeat, shortness of breath, feeling of in-

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Conclusion