Abstract
Introduction . The peculiarity of the clinical course of asthma in obese children allowed to identify a special phenotype, when the presence and severity of obesity determine a more severe course of asthma, which can serve as a criterion for predicting the worst response to asthma therapy. Asthma, like obesity, is recognized as a classic example of multi-factorial diseases, which are based on a fairly complex gene network. Investigating the genetic basis of both of these complex traits and linking them to the asthma phenotype should improve our understanding of the overall genetic basis of these pathological disorders. Aim . Review of the literature containing research data on available candidate genes that match asthma and obesity to present the current state of the issue, understand the direction of research, and solve problems. Materials and methods. The analysis of publications containing the results of the study of the effect of ADRB2 gene polymorphisms on the course of asthma in obese patients was carried out. Results. The analysis data shows that in general, the literature data on this problem is contradictory. It is emphasized that the strength of the relationship between the presence of predisposition gene polymorphisms is not always sufficient to explain the relationship between asthma and obesity, which leaves many unresolved issues that require further study. Conclusion . The analysis of genetic markers of asthma and obesity indicates the need for a comprehensive approach to research, which will contribute to the improvement and optimization of diagnostic and therapeutic measures.
Highlights
which can serve as a criterion for predicting the worst response
them to the asthma phenotype should improve our understanding of the overall genetic basis of these pathological disorders
Review of the literature containing research data on available candidate genes that match asthma and obesity to present the current state of the issue
Summary
Полиморфизм гена ADRB2 у детей с бронхиальной астмой и ожирением // Бюллетень физиологии и патологии дыхания. По данным исследований мутация в гене ADRB2 у детей с БА встречалась в 2 раза чаще по Arg16Gly и в 3 раза чаще по Gln27Glu, чем у практически здоровых детей, что оказывает влияние на механизм естественного функционирования β2-адренергического рецептора и играет важную роль в распространенности и тяжести астмы и является потенциальным инструментом для анализа риска в популяции [22, 24, 27]. M.D’Amato et al считают, что полиморфизмы β2-адренергического рецептора не связаны с астмой как таковой, а связаны с гиперчувствительностью бронхов [32], а обнаруженные значительные связи между ADRB2 Arg/Gly16 и астмой в азиатской популяции, не подтвердились результатами исследований других авторов [33, 34].
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