Abstract

PARP2017, a meeting on ADP-ribosylation reactions, was held in Budapest (17–19 May 2017).[...]

Highlights

  • The event is held every two years in Europe, alternating with the USA session, held at Cold Spring

  • There are 15 genes coding for ADP-ribosyl transferases (ARTs) proteins, named PARPs (PARP1–PARP16)

  • An evolutionary conservation and divergence among primates and non-mammal species of specific regions of PARP9, 14 and 15, PARP13 (ZAP), and PARP4 involved in the Vault complex [2]

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Summary

Introduction

The event is held every two years in Europe, alternating with the USA session, held at Cold Spring. ADP-ribosyl transferases (ARTs) are enzymes that add poly-ADP-ribose (PARylation) and mono-ADP-ribose (MARylation) to proteins. ADP-ribosylation is a reversible post-translational modification (PTM) that is thought to modify very few amino acids, mainly glutamate residues, with mono-ADP-ribose (MAR) or poly-ADP-ribose (PAR).

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