Abstract
We have shown that hypertension in rats with chronic placental ischemia (RUPP) is associated with elevated TNF-á and IL-6, AT1-AA and recently, CD4+T cells; all of which are elevated in preeclamptic women. However, it is unknown if CD4+T cells increase blood pressure or stimulate the AT1-AA in response to placental ischemia. We hypothesize that RUPP induced CD4+Tcells increase blood pressure via AT1-AA production during pregnancy. Magnetically separated CD4+Tcells isolated from spleens of RUPP and normal pregnant rats (NP) on day 19 of gestation were injected IP into NP rats at day 13 of gestation. On day 18, arterial catheters were inserted, and on day 19 blood pressure (MAP) was analyzed and serum collected for AT1-AA analysis. MAP increased from 104+2 NP to 124+2 mmHg in RUPP rats (P<0.01) and to 118+1 in NP+RUPPCD4+T cells (P<0.01) but not in NP+NPCD4+T cells (109+3.4). Circulating AT1-AA increased in NP+RUPPCD4+ T rats, 0.22+0.1 beats per minute (BPM) and to 23+0.7 (P<0.01) BPM in NP+NPCD4+Tcell rats. To determine a role for AT1-AA to mediate hypertension in response to RUPP CD4+Tcells, another group of rats was treated for AT1 receptor blockade, Losartan 10 mg/kg/day. Hypertension in response to RUPPCD4+Tcells was blocked by administration of Losartan, (102+4 mmHg). We can conclude that CD4+T lymphocytes activated in response to placental ischemia induce hypertension via AT1-AA during pregnancy.
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