Abstract
Neonatally induced tolerance in mice was adoptively transferred with living splenocytes into normal immunocompetent syngeneic adult recipients. It was also transferred passively with antisera from tolerant mice into syngeneic neonatal recipients. Immune splenocytes transferred anamnestic responsiveness rather than tolerance. No free antibody was detected by heat elution from tolerant spleen cells, but it was found in a form complexed with antigen and dissociable with acid. These results together with those reported in the accompanying paper on neonatal tolerance suggest a role for antibody in the induction and maintenance of this model of tolerance.
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