Abstract
The intrathymic versus extrathymic influences on H-2-restriction specificity of K,D- and I-region-restricted Sendai virus-immune T lymphocytes, which mediate a delayed-type hypersensitivity response in vivo, were investigated. K,D- and I-region-restricted Td lymphocytes of P1 leads to F1 fetal liver chimeras showed preference but no absolute restriction for the P1 haplotype. T effector lymphocytes of thymic chimeras expressed a slightly higher degree of restriction for the haplotype of the thymus graft than F1 leads to P1 chimeras, which might reflect the activity of T lymphocytes of thymic origin. The lack of absolute restriction of both K,D- and I-region-restricted Td lymphocytes to the haplotype the thymus suggests an additional pathway of T-cell maturation.
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