Adoption of Hypofractionated Whole-Breast Irradiation for Ductal Carcinoma In Situ Patients After Breast Conservation Surgery

Abstract

of stage and tumor site between the two groups. The Mann-Whitney U test was used to compare the remaining parameters between the two groups. Analysis was performed using SPSS v.19. Results: There was no significant difference in the distribution of stage (pZ0.19), tumor site (pZ0.63), age (pZ0.99), clinical target volume (CTV) V50 (pZ0.07) and volume of CTV (pZ0.23), heart (pZ0.30), and liver (pZ0.37) between the non-ABC and ABC groups. For all 166 patients, there was a significantly lower ipsilateral lung V5 (pZ0.001), ipsilateral lung V10 (p<0.001), ipsilateral lung V20 (p<0.001), mean ipsilateral lung dose (p<0.001), whole lung V5 (pZ0.009), whole lung V10 (p<0.001), whole lung V20 (p<0.001), mean whole lung dose (p<0.001), heart V10 (pZ0.005), heart V30 (pZ0.004), heart V40 (pZ0.010), and mean heart dose (pZ0.001) in the ABC group. For 81 patients with a leftsided breast tumor, significantly lower ipsilateral lung V5 (pZ0.004), ipsilateral lung V10 (p<0.001), ipsilateral lung V20 (p<0.001), mean ipsilateral lung dose (p<0.001), heart V10 (p<0.001), heart V30 (p<0.001), heart V40 (p<0.001), and mean heart dose (p<0.001) were observed in the ABC group. For 85 patients with a right-sided breast tumor, significantly lower ipsilateral lung V10 (pZ0.002), ipsilateral lung V20 (p<0.001), mean ipsilateral lung dose (p<0.001), heart V10 (pZ0.006), heart V30 (pZ0.008), mean heart dose (p<0.001), liver V30 (p<0.001), and mean liver dose (p<0.001) were observed in the ABC group. Conclusion: For early-stage breast cancer patients, mDIBH reduces not only the heart dose but also the lung and liver doses. Our study showed that mDIBH can significantly reduce the heart and lung dose for all breast cancer patients and also reduce the liver dose for right-sided breast cancer patients. The routine integration of mDIBH using an ABC device may decrease radiation-induced toxicity in the heart, lung, and liver. Author Disclosure: C. Lin: None.