Abstract
<strong>Introduction:</strong> UVC may induce oxidative stress mediated by ROS. <em>Pimpinella alpina</em> Molk (PaM) have been utilized by aging male as rejuvenation remedy. <strong>Objective:</strong> To elucidate the PaM effect on oxidative stress biomarker in rats. <strong>Methods:</strong> 25 of Sprague-Dawley male rats were divided into 5 groups, PaM with a dosage of 50, 100, and 150 mg were administered during 15 days to evaluate the biomarker of oxidative stress following UVC irradiation for 30 minutes beforehand. The oxidative stress biomarkers were measured by TBARS and FRAP assay respectively. <strong>Results:</strong> Post Hoc analysis demonstrated that MDA and 8-OHdG concentration in PaM group were significantly lower (p &lt; 0.001), otherwise the concentration of TAC in PaM group were significantly higher, p &lt; 0.001. <strong>Conclusion:</strong> Administration of PaM with 50, 100, and 150 mg dosage capable of improving oxidative stress biomarker in Sprague-Dawley male rats.
Highlights
A(INbH)satnrdaPcenttylenetetrazole (PTZ) induced seizures and significantly inhibited the attenuation of brain Gamma-Amino Butyric Acid (GABA) levels by INH and PTZ in mice
The objective of the present study is to investigate the effect of a PaM extract to decrease MDA and 8-OHdG levels and otherwise increase Glutathione Peroxides (GPx) level and Total Antioxidant Capacity (TAC) as a marker of declining cellular oxidative stress reflecting precocious biological aging[26]
The highest level of MDA was in Negative control group (Neg-C) group, followed by a group of PaM-50, PaM-100, PaM-150, and the lowest was in Normal control group (Nor-C) group
Summary
A(INbH)satnrdaPcenttylenetetrazole (PTZ) induced seizures and significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. VThCemteastydirnudguaclseooinxhidibaitievdethsetraepsosmmoerpdhiaintedindbuyceRdOcSli.mPbimingpiannedllsatearelpoitnyapeMd boelkha(vPiaoMr a)ndhashvoewbeeden utilized sibgnyifaicgainntglymreadleucaesd rleevjuevlseonfatbiroaninredompeadmyi.neO,bnjoercatdivreen: aTloineelauncdidsaetreottohneinPawMhicehffmecaty obne douxeidatotivbelocsktrinegssobf icoemntararkl er in rats
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