Administration of Parthenolide extract (ACT001) improved autophagy and attenuate inflammatory in Rats with ARDS

Abstract

IntroductionACT001 is widely used for the treatment of glioblastomas, breast cancers, and leukemic and the mechanism underlying the effect is anti-inflammatory. However, whether ACT001 has any effects on acute respiratory distress syndrome (ARDS) is not clear. ObjectivesTo investigate whether ACT001 helps to reduce mortality and pneumonedema after ARDS, and explore whether the mechanism is related to balance autophagy and inflammatory response. MethodsIn this study, a rat model based on CLP was used to explore the potency of ACT001 in ARDS. The expression of the autophagy-related protein, lung injuries, cytokines, and inflammatory-related protein was assessed. ResultsCompared with CLP group, ACT001 improved the survival rate, and lung wet-to-dry weight ratio. ACT001 activates autophagy, which is involved in the pathophysiologic process of sepsis, balancing the cytokine excessive release and lung injury in ARDS. ConclusionACT001 reduces mortality through improved autophagy and attenuates inflammation after ARDS.