Abstract
Background: Oxidative stress plays a role in the obesity mechanism, thus leads to premature aging. High antioxidant capacity in Bajakah tampala stem may effectively lessen oxidative stress and reduce fat mass and body weight accordingly. This study aimed to provide Bajakah tampala stem extract's effect in lowering ROS level, visceral fat weight, and overall weight of obese male Wistar rats.
 Method: A true experimental design was conducted on male Wistar rats aged 2-3 months with obesity. Thirty-two obese rats were evenly divided into a placebo group and a group given Bajakah tampala stem extract, with 16 rats in each group. For 28 days, both groups were fed a high-fat diet. The subject body weights were weighed every week. ROS levels and visceral fat weight were evaluated after the intervention was done. Comparative analysis between groups was performed.
 Results: The results showed mean levels of ROS (56.2 ± 7.4 U/ml vs. 400.9 ± 50.7 U/ml; p < 0.001), visceral fat weight (2.6 ± 0.2 g vs. 3.4 ± 0.9 g; p < 0.001), and the final body weight (241.5 ± 2.8 g vs. 261.5 ± 13.8 g; p < 0.001) were significantly lower in the study group than the control group.
 Conclusion: The study indicates Bajakah tampala stem extract administration effectively reduced ROS levels, visceral fat weight, and body weight in obese male Wistar rats.
Highlights
Excess fat that accumulates in the body is known to trigger inflammation in the body due to the release of bioactive substances, which will lead to the formation of excessive reactive oxygen species (ROS)
The results showed that the mean bodyweights of the study group were relatively lower than the control group
The comparison analysis indicated that the mean of ROS levels (U/mL) in the study group was significantly lower than the control group (p = 0.000)
Summary
Excess fat that accumulates in the body is known to trigger inflammation in the body due to the release of bioactive substances, which will lead to the formation of excessive reactive oxygen species (ROS). In a study with obese mice, oxidative stress was found to occur mostly in adipose tissue but not in the liver, skeletal muscle, and aorta This means that in obese, adipose tissue is the primary source of the formation of ROS.[4] The morbidity and mortality rates for obese individuals are relatively high due to many complications. High antioxidant capacity in Bajakah tampala stem may effectively lessen oxidative stress and reduce fat mass and body weight . This study aimed to provide Bajakah tampala stem extract's effect in lowering ROS level, visceral fat weight, and overall weight of obese male Wistar rats. Conclusion: The study indicates Bajakah tampala stem extract administration effectively reduced ROS levels, visceral fat weight, and body weight in obese male Wistar rats
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
