Administration of Anticonvulsant Drugs by the Intraperitoneal Route

Abstract

SuleymanDemirel Universitesi TIP FAKULTESI DERGISI: 1999 Eylul; 6(3) Administration ofAnticonvulsant Drugs by the Intraperitoneal Route Rusen Dundaroz, Tuncer Degim, Ali Sizlan, Mehmet Yasar, Metin Denli, Ugur Tamer Abstract Status epilepticus or seizures cause serious brain damages and irreversible cerebral injury if it prolongs and it is essential to terminate seizure rapidly. Antiepileptic drugs can be introduced to the patients intravenously (IV), hut it is almost impossible to achieve IV access during the seizure. Intraperitoneal (IP) route can be accessible but, IP route of administration of antiepileptic drugs has not been used so far. Therefore the possibility of IP administration of anti epileptic drugs was investigated in this study. Antiepileptic drug (diazepam, phenytoin or phenobarbital) was introduced rabbits and dogs by IV and IP routes and blood samples were collected by the time during the period of 60 to 120 minutes. Blood samples vere analyzed and drug contents -were determined. The plasma profiles of antiepileptic drugs were obtained and compared. The plasma profiles of antiepileptic drugs were found to be low when they were administered by IP route. It was concluded that the IP administration of antiepileptic drugs could not be an alternative route to IV administration. Key Words: Convulsion, anticonvulsant drugs, Intraperitoneal route Antikonvulzon Ilaclarin Intraperitonal Yoldan Verilmeleri Ozet Epilepsi veya epilepsi nobeti ciddi beyin hasarlarina neden olabilir, ve eger fazla uzun surerse geri donussuz beyin harabiyetine neden olabilir, bu nedenle nobetin suratle durdurulmasi oldukca onemlidir. Antiepileptik ilaclar hastalara intravenoz(IV) yolla verilebilir ancak nobetler esnasinda hastaya IV ulasim hemen hemen imkansizdir ancak intraperitonal(IP)yol ile ilac verilmesi mumkundur.