Abstract
Lipid peroxidation in homogenates of spleen, liver and lungs of rats was tested by the thiobarbituric acid method in the presence or in the absence of exogenous ferrous ions and ascorbic acid. A mild increase of stimulated lipid peroxidation was observed in liver of rats with carrageenin hind paw edema only 3 hr after the injection. In the Freund's adjuvant treated rats a dramatic suppresion of liver but not spleen and lungs lipid peroxidation was found at days 1–21 after the injection. This phenomenon was not correlated with the observed splenohepatomegaly. It is probably the result of the damage of an enzymic or non-enzymic mechanism which induces lipid peroxidation in the liver.
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