Abstract
Although adjuvant therapy of melanoma with interferon alfa is widely used in different doses, schedules, and routes of administration throughout the world, the regimen remains highly controversial.1,2 The controversy centres on whether the efficacy (particularly in terms of improved survival) relative to the toxicity of therapy is sufficient to justify such routine use. Pegylated interferon, widely used for the treatment of hepatitis, seems to be at least equally efficacious as standard recombinant interferon in the treatment of metastatic melanoma, and the available evidence suggests that equi-efficacious doses have somewhat lower acute toxicity.
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