Abstract
Myelin‐derived sulfatide (3′‐sulfagalactosyl ceramide) is a self‐glycolipid ligand recognized by a subset of CD1d‐restricted type II NKT cells. Here we show that treatment of mice with an immunodominant isoform of sulfatide inhibits the chronic and relapsing course of experimental autoimmune encephalomyelitis (EAE) in SJL/J mice. However the regulatory effect is lost upon administration of sulfatide lipid with complete Freund's adjuvant.Using PLP139–151/As‐tetramer and intracytoplasmic cytokine staining techniques we have examined the frequency of and cytokine secretion by pathogenic T cells in lymph nodes as well as in CNS. Our data indicate an increased number of PLP‐reactive Th1‐like cells and enhanced microglial activation in mice co‐challenged with lipid and adjuvant. These results indicate that activation of type II NK T cells in the presence of strong adjuvant is ineffective in the treatment of T cell‐mediated autoimmune diseases. (Supported by grants from the NIH, MSNRC to VK).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
